Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC7280146 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Zhang Heng H Li Qingjie Q Teng Yuxin Y Lin Yubi Y Li Shaojian S Qin Tingfeng T Chen Linxi L Huang Jiana J Zhai Hening H Yu Quan Q Xu Geyang G
Acta pharmaceutica Sinica. B 20200107 5
Interleukin-27 (IL-27), a heterodimeric cytokine, plays a protective role in diabetes. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate food intake. The relationship between IL-27 and ghrelin is still unexplored. Here we investigated that signal transducer and activator of transcription 3 (STAT3)-mechanistic target of rapamycin (mTOR) signaling mediates the suppression of ghrelin induced by IL-27. Co-localization of interleukin 27 receptor subunit a ...[more]