The relationship between iron metabolism, stress hormones, and insulin resistance in gestational diabetes mellitus.

ABSTRACT: AIM:To analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress in gestational diabetes mellitus (GDM). METHODS:From January to November 2019, 75 patients with GDM were selected as GDM group, according to age of 1:1; 75 normal pregnant women were selected as Control group. Blood glucose, insulin, stress hormones such as cortisol, norepinephrine (NE), and epinephrine (E), and iron metabolism index such as serum iron, serum ferritin (SF), and transferrin saturation (TS) were measured. Insulin resistance was evaluated by homeostasis model insulin resistance index (HOMA-IR). Multiple linear regression was used to analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress. RESULTS:The levels of NE, E, serum iron, SF, and TS saturation in the GDM group were higher than Control group (t?=?3.82, 2.75, 3.14, 6.12, and 3.90, P?

SUBMITTER: Feng Y 

PROVIDER: S-EPMC7280284 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature