Ontology highlight
ABSTRACT:
SUBMITTER: Cho Y
PROVIDER: S-EPMC7280434 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in oncology 20200602
Multidrug resistance (MDR), which is a significant impediment to the success of cancer chemotherapy, is attributable to various defensive mechanisms in cancer. Initially, overexpression of ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp) was considered the most important mechanism for drug resistance; hence, many investigators for a long time focused on the development of specific ABC transporter inhibitors. However, to date their efforts have failed to develop a clinically ...[more]