Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7280515 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Li Linxi L Mao Baiping B Wu Siwen S Li Huitao H Lv Lixiu L Ge Renshan R Cheng C Yan CY
Cell death & disease 20200608 6
Laminin-α2 chain is one of the major constituent proteins of the basement membrane in the mammalian testis. The laminin-type globular (LG) domains of LG3, 4 and 5 (LG3/4/5, an 80 kDa fragment) can be cleaved from laminin-α2 chain at the C-terminus via the action of matrix metalloproteinase 9 (MMP-9). This LG3/4/5 is a biologically active fragment, capable of modulating the Sertoli cell blood-testis barrier (BTB) function by tightening the barrier both in vitro and in vivo. Overexpression of LG3/ ...[more]