Dataset Information

Low serum DHEA-S is associated with impaired lung function in women.

ABSTRACT:

Background

Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS).

Methods

Lung function and serum DHEA-S concentrations were measured in n?=?2,045 and n?=?1,725 women in 1999-2002 and in 2010-2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999-2002 with incidence of restrictive pattern and airflow limitation in 2010-2013 were also assessed.

Findings

Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14).

Interpretation

Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.

Funding

EU H2020, grant agreement no.633212.

SUBMITTER: Pesce G

PROVIDER: S-EPMC7280766 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Low serum DHEA-S is associated with impaired lung function in women.

Pesce Giancarlo G Triebner Kai K van der Plaat Diana A DA Courbon Dominique D Hustad Steinar S Sigsgaard Torben T Nowak Dennis D Heinrich Joachim J Anto Josep M JM Dorado-Arenas Sandra S Martinez-Moratalla Jesús J Gullon-Blanco Jose A JA Sanchez-Ramos José L JL Raherison Chantal C Pin Isabelle I Demoly Pascal P Gislason Thorarinn T Torén Kjell K Forsberg Bertil B Lindberg Eva E Zemp Elisabeth E Jogi Rain R Probst-Hensch Nicole N Dharmage Shyamali C SC Jarvis Debbie D Garcia-Aymerich Judith J Marcon Alessandro A Gómez-Real Francisco F Leynaert Bénédicte B

EClinicalMedicine 20200606

<h4>Background</h4>Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS) ...[more]

PMID: 32529179

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Project description:PurposeWe investigate whether responses on a Low Luminance Questionnaire (LLQ) in patients with a range of age-related macular degeneration (AMD) severity are associated with their performance on focal dark adaptation (DA) testing and with choroidal thickness.DesignCross-sectional, single-center, observational study.ParticipantsA total of 113 participants older than 50 years of age with a range of AMD severity.MethodsParticipants answered the LLQ on the same day they underwent DA testing using a focal dark adaptometer measuring rod intercept time (RIT). We performed univariable and multivariable analyses of the LLQ scores and age, RIT, AMD severity, subfoveal choroidal thickness [SFCT], phakic status, and best-corrected visual acuity.Main outcome measuresThe primary outcome of this study was the score on the 32-question LLQ. Each item in the LLQ is designated to 1 of 6 subscales describing functional problems in low luminance: driving, emotional distress, mobility, extreme lighting, peripheral vision, and general dim lighting. Scores were computed for each subscale, in addition to a weighted total mean score.ResultsResponses from 113 participants (mean age, 76.2±9.3 years; 58.4% were female) and 113 study eyes were analyzed. Univariable analysis demonstrated that lower scores on all LLQ subscales were correlated with prolonged DA testing (longer RIT) and decreased choroidal thickness. All associations were statistically significant except for the association of choroidal thickness and "peripheral vision." The strongest association was the LLQ subscale of driving with RIT (r =-0.97, P < 0.001). Multivariable analysis for each of the LLQ subscale outcomes, adjusted for age, included RIT, with total LLQ score, "driving," "extreme lighting," and "mobility" also including choroidal thickness. In all multivariable analyses, RIT had a stronger association than choroidal thickness.ConclusionsThis cross-sectional analysis demonstrates associations of patient-reported functional deficits, as assessed on the LLQ, with both reduced DA and reduced choroidal thickness, in a population of older adults with varying degrees of AMD severity and good visual acuity in at least 1 eye. These analyses suggest that local functional measurements of DA testing (RIT) and choroidal thickness are associated with patient-reported functional deficits.

Dataset Information

Low serum DHEA-S is associated with impaired lung function in women.

Background

Methods

Findings

Interpretation

Funding

Publications

Low serum DHEA-S is associated with impaired lung function in women.

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