?? TCR Recognition of MR1: Adapting to Life on the Flip Side.
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ABSTRACT:
SUBMITTER: Willcox BE
PROVIDER: S-EPMC7280785 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
γδ TCR Recognition of MR1: Adapting to Life on the Flip Side.
Willcox Benjamin E BE Mohammed Fiyaz F Willcox Carrie R CR
Trends in biochemical sciences 20200413 7
Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition. ...[more]
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