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Acquired Resistance to Immune Checkpoint Blockade Therapies.

ABSTRACT: Immune checkpoint blockade therapy (ICBT) has revolutionized the treatment and management of numerous cancers, yet a substantial proportion of patients who initially respond to ICBT subsequently develop resistance. Comprehensive genomic analysis of samples from recent clinical trials and pre-clinical investigation in mouse models of cancer provide insight into how tumors evade ICBT after an initial response to treatment. Here, we summarize our current knowledge on the development of acquired ICBT resistance, by examining the mechanisms related to tumor-intrinsic properties, T-cell function, and tumor-immune cell interactions. We discuss current and future management of ICBT resistance, and consider crucial questions remaining in this field of acquired resistance to immune checkpoint blockade therapies.

SUBMITTER: Zhao X

PROVIDER: S-EPMC7280955 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Acquired Resistance to Immune Checkpoint Blockade Therapies.

Zhao Xianda X Wangmo Dechen D Robertson Matthew M Subramanian Subbaya S

Cancers 20200505 5

Immune checkpoint blockade therapy (ICBT) has revolutionized the treatment and management of numerous cancers, yet a substantial proportion of patients who initially respond to ICBT subsequently develop resistance. Comprehensive genomic analysis of samples from recent clinical trials and pre-clinical investigation in mouse models of cancer provide insight into how tumors evade ICBT after an initial response to treatment. Here, we summarize our current knowledge on the development of acquired ICB ...[more]

PMID: 32380703

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