Ontology highlight
ABSTRACT:
SUBMITTER: Karai E
PROVIDER: S-EPMC7280963 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Karai Edina E Szebényi Kornélia K Windt Tímea T Fehér Sára S Szendi Eszter E Dékay Valéria V Vajdovich Péter P Szakács Gergely G Füredi András A
Cancers 20200429 5
<h4>Background</h4>Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR). One of the main contributors of MDR is the overexpression P-glycoprotein (Pgp), which recognizes and extrudes various chemotherapeutics from cancer cells.<h4>Methods</h4>To study mechanisms underlying the development of drug resistance, we established an in vitro treatment protocol to rapidly induce Pgp-mediated MDR in cancer cells. Based ...[more]