Ontology highlight
ABSTRACT:
SUBMITTER: Yoo J
PROVIDER: S-EPMC7280979 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Yoo Jung J Jeon Yu Hyun YH Cho Ha Young HY Lee Sang Wu SW Kim Go Woon GW Lee Dong Hoon DH Kwon So Hee SH
Cancers 20200428 5
Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1 histone demethylases that promote gene expression. The KDM3 subfamily primarily consists of four proteins (KDM3A-D). All four proteins contain the catalytic Jumonji C domain (JmjC) at their C-termini, but whether KDM3C has demethylase activity is under debate. In addition, KDM3 proteins contain a zinc-finger domain for DNA binding and an LXXLL motif for interacting with nuclear receptors. Of the KDM3 proteins, KDM3A ...[more]