Unknown

Dataset Information

0

The Effects of the Marine-Derived Polysaccharides Laminarin and Chitosan on Aspects of Colonic Health in Pigs Challenged with Dextran Sodium Sulphate.


ABSTRACT: This study examined the effects of dietary supplementation with laminarin or chitosan on colonic health in pigs challenged with dextran sodium sulphate (DSS). Weaned pigs were assigned to: (1) a basal diet (n = 22); (2) a basal diet + laminarin (n = 10); and (3) a basal diet + chitosan (n = 10). On d35, the basal group was split, creating four groups: (1) the basal diet (control); (2) the basal diet + DSS; (3) the basal diet + laminarin + DSS; and (4) the basal diet + chitosan + DSS. From d39-42, the pigs were orally challenged with DSS. On d44, colonic tissue/digesta samples were collected. The basal DSS group had reduced growth, higher pathology score and an increased expression of MMP1, IL13 and IL23 compared with the controls (p < 0.05); these parameters were similar between the DSS-challenged groups (p > 0.05). In the basal DSS group, the relative abundance of beneficial taxa including Prevotella and Roseburia were reduced while Escherichia/Shigella were increased, compared with the controls (p < 0.05). The relative abundance of Escherichia/Shigella was reduced and the molar proportions of acetate were increased in the laminarin DSS group compared with the basal DSS group (p < 0.01), suggesting that laminarin has potential to prevent pathogen proliferation and enhance the volatile fatty acid profile in the colon in a porcine model of colitis.

SUBMITTER: Rattigan R 

PROVIDER: S-EPMC7281012 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Effects of the Marine-Derived Polysaccharides Laminarin and Chitosan on Aspects of Colonic Health in Pigs Challenged with Dextran Sodium Sulphate.

Rattigan Ruth R   O'Doherty John V JV   Vigors Stafford S   Ryan Marion T MT   Sebastiano Rocco S RS   Callanan John J JJ   Thornton Kevin K   Rajauria Gaurav G   Margassery Lekha M LM   Dobson Alan D W ADW   O'Leary Niall D ND   Sweeney Torres T  

Marine drugs 20200516 5


This study examined the effects of dietary supplementation with laminarin or chitosan on colonic health in pigs challenged with dextran sodium sulphate (DSS). Weaned pigs were assigned to: (1) a basal diet (n = 22); (2) a basal diet + laminarin (n = 10); and (3) a basal diet + chitosan (n = 10). On d35, the basal group was split, creating four groups: (1) the basal diet (control); (2) the basal diet + DSS; (3) the basal diet + laminarin + DSS; and (4) the basal diet + chitosan + DSS. From d39-42  ...[more]

Similar Datasets

2013-09-03 | GSE42768 | GEO
2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress
| S-EPMC4422836 | biostudies-literature
2008-11-01 | GSE9281 | GEO
| S-EPMC5740260 | biostudies-literature
2008-11-13 | E-GEOD-9281 | biostudies-arrayexpress
| S-EPMC9328732 | biostudies-literature
| S-EPMC6728368 | biostudies-literature
| S-EPMC3681816 | biostudies-literature
| S-EPMC6348411 | biostudies-literature