Ontology highlight
ABSTRACT:
SUBMITTER: Balduit A
PROVIDER: S-EPMC7281165 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Balduit Andrea A Agostinis Chiara C Mangogna Alessandro A Maggi Veronica V Zito Gabriella G Romano Federico F Romano Andrea A Ceccherini Rita R Grassi Gabriele G Bonin Serena S Bonazza Deborah D Zanconati Fabrizio F Ricci Giuseppe G Bulla Roberta R
Cancers 20200507 5
The development of personalized therapies for ovarian carcinoma patients is still hampered by several limitations, mainly the difficulty of predicting patients' responses to chemotherapy in tumor cells isolated from peritoneal fluids. The main reason for the low predictive power of in vitro assays is related to the modification of the cancer cells' phenotype induced by the culture conditions, which results in changes to the activation state and drug sensitivity of tumor cells compared to their i ...[more]