Establishment and Validation of an Individualized Cell Cycle Process-Related Gene Signature to Predict Cancer-Specific Survival in Patients with Bladder Cancer.
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ABSTRACT:
SUBMITTER: Shi R
PROVIDER: S-EPMC7281226 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Establishment and Validation of an Individualized Cell Cycle Process-Related Gene Signature to Predict Cancer-Specific Survival in Patients with Bladder Cancer.
Shi Run R Bao Xuanwen X Rogowski Paul P Schäfer Christian C Schmidt-Hegemann Nina-Sophie NS Unger Kristian K Lu Shun S Sun Jing J Buchner Alexander A Stief Christian C Belka Claus C Li Minglun M
Cancers 20200502 5
More accurate models are essential to identify high-risk bladder cancer (BCa) patients who will benefit from adjuvant therapies and thus helpful to facilitate personalized management of BCa. Among various cancer-related hallmarks and pathways, cell cycle process (CCP) was identified as a dominant risk factor for cancer-specific survival (CSS) in BCa. Using a series of bioinformatic and statistical approaches, a CCP-related gene signature was established, and the prognostic value was validated in ...[more]
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