STAT3: Versatile Functions in Non-Small Cell Lung Cancer.
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ABSTRACT:
SUBMITTER: Mohrherr J
PROVIDER: S-EPMC7281271 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
STAT3: Versatile Functions in Non-Small Cell Lung Cancer.
Mohrherr Julian J Uras Iris Z IZ Moll Herwig P HP Casanova Emilio E
Cancers 20200429 5
Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in non-small cell lung cancer (NSCLC) patient samples/cell lines and STAT3 inhibition in NSCLC cell lines markedly impairs their survival. STAT3 also plays a pivotal role in driving tumor-promoting inflammation and evasion of anti-tumor immunity. Consequently, targeting STAT3 either directly or by inhibition of upstream regulators such as Interleukin-6 (IL-6) or Janus kinase 1/2 (JAK1/2) is considered as a ...[more]
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