Ontology highlight
ABSTRACT:
SUBMITTER: Loidreau Y
PROVIDER: S-EPMC7281298 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Loidreau Yvonnick Y Dubouilh-Benard Carole C Nourrisson Marie-Renée MR Loaëc Nadège N Meijer Laurent L Besson Thierry T Marchand Pascal P
Pharmaceuticals (Basel, Switzerland) 20200509 5
We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC<sub>50</sub> values. For the generation of chemical libraries, the formamide-mediated cyclization of the cyanoamidine precursors was carried out under microwave irradiation in an eco-friendly approach. In order to explore more in-depth the pharmacological interest in such tricyclic skeletons, the central five member ring, i.e., thiop ...[more]