Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis.
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ABSTRACT:
SUBMITTER: Kuriu S
PROVIDER: S-EPMC7281316 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis.
Kuriu Satoru S Kadonosono Tetsuya T Kizaka-Kondoh Shinae S Ishida Tadashi T
Micromachines 20200506 5
Microfluidic devices utilizing spheroids play important roles in in vitro experimental systems to closely simulate morphological and biochemical characteristics of the in vivo tumor microenvironment. For the observation and analysis of the inner structure of spheroids, sectioning is an efficient approach. However, conventional microfluidic devices are difficult for sectioning, and therefore, spheroids inside the microfluidic channels have not been sliced well. We proposed a microfluidic device c ...[more]
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