Ontology highlight
ABSTRACT:
SUBMITTER: Wang IH
PROVIDER: S-EPMC7281414 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wang I-Han IH Huang Tzu-Ting TT Chen Ji-Lin JL Chu Li-Wei LW Ping Yueh-Hsin YH Hsu Kai-Wen KW Huang Kuo-Hung KH Fang Wen-Liang WL Lee Hsin-Chen HC Chen Chian-Feng CF Liao Chen-Chung CC Hsieh Rong-Hong RH Yeh Tien-Shun TS
Cancers 20200427 5
The 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) is a potential regulatory node in the mevalonate pathway that is frequently dysregulated in tumors. This study found that HMGCS1 expression is upregulated in stomach adenocarcinoma samples of patients and tumorspheres of gastric cancer cells. HMGCS1 elevates the expression levels of the pluripotency genes Oct4 and SOX-2 and contributes to tumorsphere formation ability in gastric cancer cells. HMGCS1 also promotes in vitro cell growth and pro ...[more]