Ontology highlight
ABSTRACT:
SUBMITTER: Luo J
PROVIDER: S-EPMC7281472 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Luo Jiao J Hou Yufei Y Xie Mengyue M Ma Wanli W Shi Dayong D Jiang Bo B
Marine drugs 20200519 5
3-bromo-4,5-Bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (CYC31) is a bromophenol protein tyrosine phosphatase 1B (PTP1B) inhibitor isolated from the red alga <i>Rhodomela confervoides</i>. Here, the effect of CYC31 on the insulin signaling and fatty-acid-induced disorders in C2C12 myotubes was investigated. Molecular docking assay showed that CYC31 was embedded into the catalytic pocket of PTP1B. A cellular study found that CYC31 increased the activity of insulin signaling and promoted ...[more]