Unknown

Dataset Information

0

Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205.

ABSTRACT: Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A-C (3-5) were identified from mangrove Streptomyces qinglanensis 172205 with "genetic dereplication," which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 2-4 showed weak antiproliferative activities.

SUBMITTER: Xu D 

PROVIDER: S-EPMC7281499 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Bioactive Molecules from Mangrove <i>Streptomyces qinglanensis</i> 172205.

Xu Dongbo D   Tian Erli E   Kong Fandong F   Hong Kui K  

Marine drugs 20200513 5

Five new compounds 15<i>R</i>-17,18-dehydroxantholipin (<b>1</b>), (<i>3E</i>,<i>5E</i>,<i>7E</i>)-3-methyldeca-3,5,7-triene-2,9-dione (<b>2</b>) and qinlactone A-C (<b>3</b>-<b>5</b>) were identified from mangrove <i>Streptomyces qinglanensis</i> 172205 with "genetic dereplication," which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by elec  ...[more]

Similar Datasets

Unknown Bioactive metabolites produced by Streptomyces Cheonanensis VUK-A from Coringa mangrove sediments: isolation, structure elucidation and bioactivity.
| S-EPMC4752944 | biostudies-literature
Unknown Draft Genome Sequence of Bioactive Strain Streptomyces sp. SMS_SU21, Isolated from Soil Sediment of the Sundarbans Mangrove Ecosystem.
| S-EPMC6033983 | biostudies-literature
Unknown Bioactive Chaetoglobosins from the Mangrove Endophytic Fungus Penicillium chrysogenum.
| S-EPMC5082320 | biostudies-literature
Unknown Focused Review: Cytotoxic and Antioxidant Potentials of Mangrove-Derived Streptomyces.
| S-EPMC5672783 | biostudies-literature
Unknown Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG.
| S-EPMC5431850 | biostudies-literature
Unknown Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B.
| S-EPMC4446620 | biostudies-literature
Unknown Genome sequence of Streptomyces gilvigriseus MUSC 26T isolated from mangrove forest.
| S-EPMC5913758 | biostudies-literature
Unknown Secondary Metabolite Production Potential of Mangrove-Derived <i>Streptomyces olivaceus</i>.
| S-EPMC8228178 | biostudies-literature
Unknown Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3.
| S-EPMC5796933 | biostudies-literature
Unknown Bioactive Metabolites From Acid-Tolerant Fungi in a Thai Mangrove Sediment.
| S-EPMC7862741 | biostudies-literature