Ontology highlight
ABSTRACT:
SUBMITTER: Koonin EV
PROVIDER: S-EPMC7281927 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Koonin Eugene V EV Krupovic Mart M Ishino Sonoko S Ishino Yoshizumi Y
BMC biology 20200609 1
Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in t ...[more]