Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects.
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ABSTRACT:
SUBMITTER: Sewda A
PROVIDER: S-EPMC7282656 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects.
Sewda Anshuman A Agopian A J AJ Goldmuntz Elizabeth E Hakonarson Hakon H Morrow Bernice E BE Musfee Fadi F Taylor Deanne D Mitchell Laura E LE
PloS one 20200609 6
Congenital heart defects (CHDs) affect approximately 1% of newborns. Epidemiological studies have identified several genetically-mediated maternal phenotypes (e.g., pregestational diabetes, chronic hypertension) that are associated with the risk of CHDs in offspring. However, the role of the maternal genome in determining CHD risk has not been defined. We present findings from gene-level, genome-wide studies that link CHDs to maternal effect genes as well as to maternal genes related to hyperten ...[more]
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