9.4 MHz A-line rate optical coherence tomography at 1300?nm using a wavelength-swept laser based on stretched-pulse active mode-locking.

ABSTRACT: In optical coherence tomography (OCT), high-speed systems based at 1300?nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300?nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240?nm to 1340?nm, and the OCT system using this light source provides a sensitivity of 98?dB and a single-sided 6-dB roll-off depth of 2.5?mm. We present new capabilities of the 9.4?MHz SPML-OCT system in three microscopy applications. First, we demonstrate high quality OCTA imaging at a rate of 1.3 volumes/s. Second, by utilizing its inherent phase stable characteristics, we present wide dynamic range en face Doppler OCT imaging with multiple time intervals ranging from 0.25?ms to 2.0?ms at a rate of 0.53 volumes/s. Third, we demonstrate video-rate 4D microscopic imaging of a beating Xenopus embryo heart at a rate of 30 volumes/s. This high-speed and high-performance OCT system centered at 1300?nm suggests that it can be one of the most promising high-speed OCT platforms enabling a wide range of new scientific research, industrial, and clinical applications at speeds of 10?MHz.

SUBMITTER: Kim TS 

PROVIDER: S-EPMC7283258 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature