Ontology highlight
ABSTRACT:
SUBMITTER: Chessa C
PROVIDER: S-EPMC7283518 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chessa Céline C Bodet Charles C Jousselin Clément C Wehbe Michel M Lévêque Nicolas N Garcia Magali M
Frontiers in microbiology 20200603
Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral replication, these cells can sense virus associated molecular patterns leading to the initiation of an innate immune response composed of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. Human keratinocytes produce and secrete at lea ...[more]