Dataset Information

COVID-19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019-nCoV disease.

ABSTRACT: Months after the outbreak of a new flu-like disease in China, the entire world is now in a state of caution. The subsequent less-anticipated propagation of the novel coronavirus disease, formally known as COVID-19, not only made it to headlines by an overwhelmingly high transmission rate and fatality reports, but also raised an alarm for the medical community all around the globe. Since the causative agent, SARS-CoV-2, is a recently discovered species, there is no specific medicine for downright treatment of the infection. This has led to an unprecedented societal fear of the newly born disease, adding a psychological aspect to the physical manifestation of the virus. Herein, the COVID-19 structure, epidemiology, pathogenesis, etiology, diagnosis, and therapy have been reviewed.

SUBMITTER: Sheervalilou R

PROVIDER: S-EPMC7283670 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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COVID-19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019-nCoV disease.

Sheervalilou Roghayeh R Shirvaliloo Milad M Dadashzadeh Nahid N Shirvalilou Sakine S Shahraki Omolbanin O Pilehvar-Soltanahmadi Younes Y Ghaznavi Habib H Khoei Samideh S Nazarlou Ziba Z

Journal of cellular physiology 20200526 12

Months after the outbreak of a new flu-like disease in China, the entire world is now in a state of caution. The subsequent less-anticipated propagation of the novel coronavirus disease, formally known as COVID-19, not only made it to headlines by an overwhelmingly high transmission rate and fatality reports, but also raised an alarm for the medical community all around the globe. Since the causative agent, SARS-CoV-2, is a recently discovered species, there is no specific medicine for downright ...[more]

PMID: 32452539

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Project description:In December 2019 a novel coronavirus SARS-CoV-2 emerged in the Hunan seafood market in Wuhan, China, and soon became a global health problem. Since its outbreak, SARS-CoV-2 has had a major impact on clinical diagnostic laboratories. The scientific community has quickly risen to the occasion and reports of new developments have arrived at an unprecedented scale. At present, there is a growing list of over 400 SARC-CoV-2 diagnostic tests either in development or approved for clinical use. This presentation reviews the current laboratory methods available for testing COVID- 19 in microbiology laboratories and also provides an insight into the future diagnostics approaches. Proper respiratory specimen collected at the appropriate time and from the right anatomical site is critical in the accurate and timely diagnosis of SARSCoV2. While oropharyngeal and nasopharyngeal swabs are recommended for the detection of early infection, other lower respiratory tract specimens like the sputum and bronchoalveolar lavage are used for late detection and monitoring of patients with severe COVID-19 pneumonia. Real-time RT-PCR based molecular assay remains the test of choice for the etiological diagnosis of SARS-CoV-2 while serological tests are being introduced as supplementary tools. Finally, there is an urgent need for scaling up the diagnostic capacity by the introduction of reliable and accurate point-of-care tests which will assist in effective control of this outbreak. These assays can be used in the local hospitals and clinics bearing the burden of identifying and treating patients. Highlights • Since its outbreak, SARS-CoV-2 has had a major impact on clinical diagnostic laboratories.• At present, there is a growing list of over 400 SARC-CoV-2 diagnostic tests either in development or approved for clinical use.• Real-time RT-PCR based molecular assay remains the test of choice for the etiological diagnosis of SARS-CoV-2.• Oropharyngeal and nasopharyngeal swabs are recommended for the detection of early infection.• Lower respiratory tract specimens can be used for late detection and monitoring of patients with severe COVID-19 pneumonia.• There is an urgent need for scaling up the diagnostic capacity by the introduction of reliable and accurate point-of-care tests.

Dataset Information

COVID-19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019-nCoV disease.

Publications

COVID-19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019-nCoV disease.

Similar Datasets

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