Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC7284026 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yuan Yuying Y Chai Xianghua X Liu Na N Gu Bida B Li Shengting S Gao Ya Y Zhou Lijun L Liu Qiang Q Yang Fan F Liu Jingjuan J Qiu Jiao J Zhang Jinjin J Hou Yumei Y Cen Miaolan M Tian Zhongming Z Tang Weijiang W Zhang Hongyun H Chen Fang F Yin Ye Y Wang Wei W
Molecular genetics & genomic medicine 20200413 6
<h4>Background</h4>Noninvasive prenatal testing (NIPT) is one of the most commonly employed clinical measures for screening of fetal aneuploidy. Fetal Fraction (ff) has been demonstrated to be one of the key factors affecting the performance of NIPT. Accurate quantification of ff plays vital role in NIPT.<h4>Methods</h4>In this study, we present a new approach, the accurate Quantification of Fetal Fraction with Shallow-Coverage sequencing of maternal plasma DNA (FF-QuantSC), for the estimation o ...[more]