Dataset Information

Solution Blow Spinning of High-Performance Submicron Polyvinylidene Fluoride Fibres: Computational Fluid Mechanics Modelling and Experimental Results.

ABSTRACT: Computational fluid dynamics (CFD) was used to investigate characteristics of high-speed air as it is expelled from a solution blow spinning (SBS) nozzle using a k-? turbulence model. Air velocity, pressure, temperature, turbulent kinetic energy and density contours were generated and analysed in order to achieve an optimal attenuation force for fibre production. A bespoke convergent nozzle was used to produce polyvinylidene fluoride (PVDF) fibres at air pressures between 1 and 5 bar. The nozzle comprised of four parts: a polymer solution syringe holder, an air inlet, an air chamber, and a cap that covers the air chamber. A custom-built SBS setup was used to produce PVDF submicron fibres which were consequently analysed using scanning electron microscope (SEM) for their morphological features. Both theoretical and experimental observations showed that a higher air pressure (4 bar) is more suitable to achieve thin fibres of PVDF. However, fibre diameter increased at 5 bar and intertwined ropes of fibres were also observed.

SUBMITTER: Atif R

PROVIDER: S-EPMC7284647 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Solution Blow Spinning of High-Performance Submicron Polyvinylidene Fluoride Fibres: Computational Fluid Mechanics Modelling and Experimental Results.

Atif Rasheed R Combrinck Madeleine M Khaliq Jibran J Hassanin Ahmed H AH Shehata Nader N Elnabawy Eman E Shyha Islam I

Polymers 20200516 5

Computational fluid dynamics (CFD) was used to investigate characteristics of high-speed air as it is expelled from a solution blow spinning (SBS) nozzle using a k-ε turbulence model. Air velocity, pressure, temperature, turbulent kinetic energy and density contours were generated and analysed in order to achieve an optimal attenuation force for fibre production. A bespoke convergent nozzle was used to produce polyvinylidene fluoride (PVDF) fibres at air pressures between 1 and 5 bar. The nozzle ...[more]

PMID: 32429457

Similar Datasets

Project description:Polymer nano/micro fibers have found many applications including 3D cell culture and the creation of wound dressings. The fibers can be produced by a variety of techniques that include electrospinning, the primary disadvantage of which include the requirement for a high voltage supply (which may cause issues such as polymer denaturation) and lack of portability. More recently, solution blow spinning, where a high velocity sheath gas is used instead of high voltage, has been used to generate polymer fibers. In this work, we used blow spinning to create nano/microfibers for microchip-based 3D cell culture. First, we thoroughly investigated fiber generation from a 3D printed gas sheath device using two polymers that are amenable to cell culture (polycaprolactone, PCL and polystyrene, PS) as well as the parameters that can affect PCL and PS fiber quality. Using the 3D printed sheath device, it was found that the pressure of the sheath N2 and the concentration of polymer solutions determine if fibers can be produced as well as the resulting fiber morphology. In addition, we showed how these fibers can be used for 3D cell culture by directly depositing PCL fibers in petri dishes and well plates. It is shown the fibers have good compatibility with RAW 264.7 macrophages and the PCL fiber scaffold can be as thick as 178 ± 14 μm. PCL fibers created from solution blow spinning (with the 3D printed sheath device) were then integrated with a microfluidic device for the first time to fabricate a 3D cell culture scaffold with a flow component. After culturing and stimulating macrophages on the fluidic device, it was found that the integrated 3D fibrous scaffold is a better mimic of the extracellular matrix (as opposed to a flat, 2D substrate), with enhanced nitrite accumulation (product of nitric oxide release) from macrophages stimulated with lipopolysaccharide. PS fibers were also made and integrated in a microfluidic device for 3D culture of endothelial cells, which stayed viable for at least 72 hours (48 hours under the flowing conditions). This approach will be useful for future studies involving more realistic microchip-based culture models for studying cell-to-cell communication.

Dataset Information

Solution Blow Spinning of High-Performance Submicron Polyvinylidene Fluoride Fibres: Computational Fluid Mechanics Modelling and Experimental Results.

Publications

Solution Blow Spinning of High-Performance Submicron Polyvinylidene Fluoride Fibres: Computational Fluid Mechanics Modelling and Experimental Results.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets