Ontology highlight
ABSTRACT:
SUBMITTER: Hacker DE
PROVIDER: S-EPMC7284801 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Hacker David E DE Abrigo Nicolas A NA Hoinka Jan J Richardson Stacie L SL Przytycka Teresa M TM Hartman Matthew C T MCT
ACS combinatorial science 20200517 6
Peptide macrocyclization is typically associated with the development of higher affinity and more protease stable protein ligands, and, as such, is an important tool in peptide drug discovery. Yet, within the context of a diverse library, does cyclization give inherent advantages over linear peptides? Here, we used mRNA display to create a peptide library of diverse ring sizes and topologies (monocyclic, bicyclic, and linear). Several rounds of in vitro selection against streptavidin were perfor ...[more]