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Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes.


ABSTRACT: The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 251922), and Candida albicans (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The minimum inhibitory concentrations (MIC) were determined for the active azo dyes. All the azo compounds (A1-B4) were screened for anthelmintic activity against adult Ghanaian earthworms, Hyperiodrilus spp. As part of the systematic investigation for biological activity, all the azo compounds exhibited good antimicrobial activity against the seven human pathogenic microorganisms. All the compounds exhibited anthelminthic activity against adult Ghanaian earthworms, Hyperiodrilus spp.

SUBMITTER: Adu JK 

PROVIDER: S-EPMC7284924 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Synthesis and <i>In Vitro</i> Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic <i>Azo</i> Dyes.

Adu Joseph Kwasi JK   Amengor Cedric Dzidzor Kodjo CDK   Mohammed Ibrahim Nurudeen N   Amaning-Danquah Cynthia C   Owusu Ansah Charles C   Gbadago Dorcas Dzifa DD   Sarpong-Agyapong Joseph J  

Journal of tropical medicine 20200601


The antimicrobial activity of 2-naphtholic and phenolic <i>azo</i> compounds was determined against seven microbial species, <i>Staphylococcus aureus</i> (ATCC 25923), <i>Streptococcus pyrogenes</i> (clinical), and <i>Enterococcus faecalis</i> (ATCC 29212), <i>Salmonella typhi</i> (clinical), <i>Pseudomonas aeruginosa</i> (ATCC 27853), <i>Escherichia coli</i> (ATCC 251922), and <i>Candida albicans</i> (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The mi  ...[more]

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