NAFLD Aggravates Septic Shock Due to Inadequate Adrenal Response and 11?-HSDs Dysregulation in Rats.

ABSTRACT: BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is linked with metabolic syndrome. Previous studies showed that obesity may disrupt adrenal function and adversely affect its counter-regulations against shock. This study hence evaluated adrenal function abnormalities in NAFLD with shock. METHODS:Sprague-Dawley rats were fed with regular chow-diet (control) or high fat diet (HFD, 60% energy derived from fat). Blood tests were performed at the end of the 4th, 6th and 8th week, respectively. Experiments were performed at the end of the 8th week. RESULTS:HFD rats developed NAFLD. HFD rats had 27% and 51% increase in plasma corticosterone at the 6th and 8th week in usual status. However, HFD rats had 5 times more reduction of mean arterial pressure in response to lipopolysaccharide-induced sepsis as compared to control rats. The corticosterone increment ratio was also lower in HFD rats, even after ACTH administration. 11?-HSD system tended to generate more corticosterone in HFD rats under hemodynamic stable status without shock and the trend was lost in HFD rats with septic shock. CONCLUSION:Rats with NAFLD had profound septic shock due to inadequate corticosterone response. This is, at least partly, due to 11?-HSDs dysregulation in sepsis.

SUBMITTER: Huang HC 

PROVIDER: S-EPMC7285211 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature