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Impact of a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), on allogeneic transplant outcomes in patients with acute myeloid leukemia and myelodysplastic syndrome.


ABSTRACT: Outcomes after allogeneic stem-cell transplantation (AHSCT) are influenced by both disease- and patient-related factors. Here, we developed a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), by combining the refined disease risk index (DRI-R) and hematopoietic stem-cell transplant comorbidity/age index (HCT-CI/Age) to predict post-transplant survival for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The analysis included 942 AML/MDS patients treated with AHSCT. Patients were stratified into 4 HCT-CR risk groups: Low-risk-patients with low/intermediate DRI-R and HCT-CI/Age??3 (N?=?272); Intermediate-risk-patients with low/intermediate DRI-R and HCT-CI/Age?>3 (N?=?168); High-risk-patients with high/very high DRI-R and HCT-CI/Age??3 (N?=?284); and Very high-risk-patients with high/very high DRI-R and HCT-CI/Age?>3 (N?=?184). Compared with the low-risk group, intermediate, high, and very high-risk groups had a significantly increased risk of death [adjusted HR of 1.37 (P?

SUBMITTER: Kongtim P 

PROVIDER: S-EPMC7285649 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Impact of a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), on allogeneic transplant outcomes in patients with acute myeloid leukemia and myelodysplastic syndrome.

Kongtim Piyanuch P   Parmar Simrit S   Milton Denái R DR   Perez Jorge Miguel Ramos JMR   Rondon Gabriela G   Chen Julianne J   Chilkulwar Abhishek R AR   Al-Atrash Gheath G   Alousi Amin A   Andersson Borje S BS   Im Jin S JS   Hosing Chitra M CM   Bashir Qaiser Q   Khouri Issa I   Kebriaei Partow P   Oran Betul B   Popat Uday U   Champlin Richard R   Ciurea Stefan O SO  

Bone marrow transplantation 20180926 6


Outcomes after allogeneic stem-cell transplantation (AHSCT) are influenced by both disease- and patient-related factors. Here, we developed a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), by combining the refined disease risk index (DRI-R) and hematopoietic stem-cell transplant comorbidity/age index (HCT-CI/Age) to predict post-transplant survival for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The analysis included 942 AML/MDS  ...[more]

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