Ontology highlight
ABSTRACT:
SUBMITTER: Chiduza GN
PROVIDER: S-EPMC7285653 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Chiduza George N GN Johnson Rachel M RM Wright Gareth S A GSA Antonyuk Svetlana V SV Muench Stephen P SP Hasnain S Samar SS
Acta crystallographica. Section D, Structural biology 20190628 Pt 7
Solute carriers are a large class of transporters that play key roles in normal and disease physiology. Among the solute carriers, heteromeric amino-acid transporters (HATs) are unique in their quaternary structure. LAT1-CD98hc, a HAT, transports essential amino acids and drugs across the blood-brain barrier and into cancer cells. It is therefore an important target both biologically and therapeutically. During the course of this work, cryo-EM structures of LAT1-CD98hc in the inward-facing confo ...[more]