Ontology highlight
ABSTRACT:
SUBMITTER: Zang R
PROVIDER: S-EPMC7285829 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Science immunology 20200501 47
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2 replicates in the human intestine and contributes to possible fecal-oral transmission. Here, we report productive infection of SARS-CoV-2 in ACE2<sup>+</sup> mature enterocytes in human small intestinal enteroids. Expression of two mucosa-specific serine proteases, TMPRSS2 and TMPRSS4, facilitated SARS-CoV-2 spike fusogenic activity and promoted v ...[more]