Ontology highlight
ABSTRACT:
SUBMITTER: Youssefian L
PROVIDER: S-EPMC7285838 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Youssefian Leila L Vahidnezhad Hassan H Saeidian Amir Hossein AH Pajouhanfar Sara S Sotoudeh Soheila S Mansouri Parvin P Amirkashani Davoud D Zeinali Sirous S Levine Michael A MA Peris Ketty K Colombo Roberto R Uitto Jouni J
Journal of hepatology 20190404 2
<h4>Background & aims</h4>Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition and the most common liver disease worldwide, affecting more than one-third of the population. So far there have been no reports on mendelian inheritance in families with NAFLD.<h4>Methods</h4>We performed whole-exome or targeted next-generation sequencing on patients with autosomal dominant NAFLD.<h4>Results</h4>We report a heritable form of NAFLD and/or dyslipidemia due to monoallelic ABHD5 mutatio ...[more]