Unknown

Dataset Information

0

Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.

ABSTRACT: Objectives:To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894?T gene polymorphisms could mediate in andrological treatment response in Spaniards. Subject patients/methods:The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n?=?105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software. Results:A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients. Conclusion:T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.

SUBMITTER: Segura A 

PROVIDER: S-EPMC7285905 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.

Segura Ana A   Ballester Pura P   Ajo Raquel R   Inda María-Del-Mar MD   Urbano Antonio A   Muriel Javier J   Ochando Isabel I   Margarit César C   Martinez Emi E   Peiró Ana M AM  

Gene: X 20190202

<h4>Objectives</h4>To investigate whether <i>endothelial nitric oxide synthase (eNOS)</i> T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.<h4>Subject patients/methods</h4>The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (<i>n</i> = 105) recruited at the Pain Unit. <i>eNOS</i> polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses we  ...[more]

Similar Datasets

Unknown Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity.
| S-EPMC4879575 | biostudies-literature
Unknown Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances.
| S-EPMC4387900 | biostudies-literature
Unknown Inducible Nitric Oxide Synthase Polymorphisms and Nitric Oxide Levels in Individuals with Chronic Periodontitis.
| S-EPMC5485952 | biostudies-literature
Unknown Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
| S-EPMC3611897 | biostudies-literature
Unknown Lack of association between endothelial nitric oxide synthase (NOS3) gene polymorphisms and suicide attempts.
| S-EPMC1914081 | biostudies-literature
Unknown Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study.
| S-EPMC3217889 | biostudies-literature
Unknown Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.
| S-EPMC6728140 | biostudies-literature
Unknown Endothelial nitric oxide synthase gene variation associated with chronic kidney disease after liver transplant.
| S-EPMC2931617 | biostudies-literature
Unknown Endothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patients.
| S-EPMC5363447 | biostudies-other
Unknown Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.
| S-EPMC3827989 | biostudies-literature