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Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.

ABSTRACT: Objectives:To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894?T gene polymorphisms could mediate in andrological treatment response in Spaniards. Subject patients/methods:The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n?=?105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software. Results:A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients. Conclusion:T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.

SUBMITTER: Segura A 

PROVIDER: S-EPMC7285905 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.

Segura Ana A   Ballester Pura P   Ajo Raquel R   Inda María-Del-Mar MD   Urbano Antonio A   Muriel Javier J   Ochando Isabel I   Margarit César C   Martinez Emi E   Peiró Ana M AM  

Gene: X 20190202

<h4>Objectives</h4>To investigate whether <i>endothelial nitric oxide synthase (eNOS)</i> T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.<h4>Subject patients/methods</h4>The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (<i>n</i> = 105) recruited at the Pain Unit. <i>eNOS</i> polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses we  ...[more]

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