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Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom.


ABSTRACT: Bothrops lanceolatus inflicts severe envenomings in the Lesser Caribbean island of Martinique. Bothrofav®, a monospecific antivenom against B. lanceolatus venom, has proven highly effective at the preclinical and clinical levels. Here, we report a detailed third-generation antivenomics quantitative analysis of Bothrofav®. With the exception of poorly-immunogenic peptides, Bothrofav® immunocaptured all the major protein components. These results, along with previous preclinical and clinical observations, underscore the high neutralizing efficacy of the antivenom against B. lanceolatus venom.

SUBMITTER: Pla D 

PROVIDER: S-EPMC7286001 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards <i>Bothrops lanceolatus</i> venom.

Pla Davinia D   Rodríguez Yania Y   Resiere Dabor D   Mehdaoui Hossein H   Gutiérrez José María JM   Calvete Juan J JJ  

Toxicon: X 20181229


<i>Bothrops lanceolatus</i> inflicts severe envenomings in the Lesser Caribbean island of Martinique. Bothrofav®, a monospecific antivenom against <i>B. lanceolatus</i> venom, has proven highly effective at the preclinical and clinical levels. Here, we report a detailed third-generation antivenomics quantitative analysis of Bothrofav®. With the exception of poorly-immunogenic peptides, Bothrofav® immunocaptured all the major protein components. These results, along with previous preclinical and  ...[more]

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