Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC7286058 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lu Yao Y Li Qilong Q Zheng Kexin K Fu Chenghao C Jiang Chunying C Zhou Dayu D Xia Chao C Ma Shiliang S
Gene: X 20190212
In metazoan genome, the mechanism of gene expression regulation between transcriptional regulatory elements and their target gene is spatiotemporal. Active promoters possess many specific chromosomal features, such as hypersensitive to DNaseI and enrichment of specific histone modifications. In this article, we proposed a novel method which possesses a high efficiency to find promoters <i>in vitro</i>. A promoter-trap library was constructed with totally 706 random mouse genomic DNA fragment clo ...[more]