Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women.
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ABSTRACT:
SUBMITTER: Prakash J
PROVIDER: S-EPMC7286079 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women.
Prakash Jai J Herlin Maria M Kumar Jitender J Garg Gaurav G Akesson Kristina E KE Grabowski Peter S PS Skerry Tim M TM Richards Gareth O GO McGuigan Fiona E A FEA
Gene: X 20190214
<h4>Background and aim</h4>The Receptor Activity Modifying Proteins (RAMPs) are a group of accessory proteins, of which there are three in humans, that interact with a number of G-protein coupled receptors (GPCR) and play various roles in regulation of endocrine signaling. Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association betw ...[more]
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