Identification of key lncRNAs in the tumorigenesis of intraductal pancreatic mucinous neoplasm by coexpression network analysis.

ABSTRACT: Intraductal papillary mucinous neoplasm (IPMN) is an intraepithelial precancerous lesion of pancreatic ductal adenocarcinoma (PDAC) that progresses from adenoma to carcinoma, and long noncoding RNAs (lncRNA) might be involved in the tumorigenesis. In this study, we obtained the expression profiles of more than 4000 lncRNAs by probe reannotation of a microarray dataset. As a correlation network-based systems biology method, weighted gene coexpression network analysis (WGCNA) was used to find clusters of highly correlated lncRNAs in the tumorigenesis of IPMN, which covered four stepwise stages from normal main pancreatic duct to invasive IPMN. In the most relevant module (R²  = -0.75 and P = 5E-05), three hub lncRNAs were identified (HAND2-AS1, CTD-2033D15.2, and lncRNA-TFG). HAND

SUBMITTER: Ding J 

PROVIDER: S-EPMC7286472 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature