A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques.
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ABSTRACT:
SUBMITTER: van Doremalen N
PROVIDER: S-EPMC7286676 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques.
van Doremalen Neeltje N Haddock Elaine E Feldmann Friederike F Meade-White Kimberly K Bushmaker Trenton T Fischer Robert J RJ Okumura Atsushi A Hanley Patrick W PW Saturday Greg G Edwards Nick J NJ Clark Madeleine H A MHA Lambe Teresa T Gilbert Sarah C SC Munster Vincent J VJ
Science advances 20200610 24
Developing a vaccine to protect against the lethal effects of the many strains of coronavirus is critical given the current global pandemic. For Middle East respiratory syndrome coronavirus (MERS-CoV), we show that rhesus macaques seroconverted rapidly after a single intramuscular vaccination with ChAdOx1 MERS. The vaccine protected against respiratory injury and pneumonia and reduced viral load in lung tissue by several orders of magnitude. MERS-CoV replication in type I and II pneumocytes of C ...[more]
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