The emerging roles of WBP2 oncogene in human cancers.
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ABSTRACT:
SUBMITTER: Tabatabaeian H
PROVIDER: S-EPMC7286818 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
The emerging roles of WBP2 oncogene in human cancers.
Tabatabaeian Hossein H Rao Angad A Ramos Alisha A Chu Tinghine T Sudol Marius M Lim Yoon Pin YP
Oncogene 20200511 24
WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI<sub>3</sub>K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomar ...[more]
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