Ontology highlight
ABSTRACT:
SUBMITTER: Tang B
PROVIDER: S-EPMC7286869 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Tang Bowen B Yuan Shuai S Xiong Ying Y He Qiqiang Q Larsson Susanna C SC
Diabetologia 20200408 7
<h4>Aims/hypothesis</h4>Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. We conducted a two-sample bidirectional Mendelian randomisation (MR) study to assess the causal associations of MDD with type 2 diabetes, coronary artery disease (CAD) and heart failure and vice versa.<h4>Methods</h4>We extracted summary-level data for MDD, type 2 diabetes, CAD and heart failure from corresponding published large genome-wide a ...[more]