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Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study.


ABSTRACT: AIMS/HYPOTHESIS:Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. We conducted a two-sample bidirectional Mendelian randomisation (MR) study to assess the causal associations of MDD with type 2 diabetes, coronary artery disease (CAD) and heart failure and vice versa. METHODS:We extracted summary-level data for MDD, type 2 diabetes, CAD and heart failure from corresponding published large genome-wide association studies of individuals mainly of European-descent. In total, 96 SNPs for MDD, 202 SNPs for type 2 diabetes, 44 SNPs for CAD and 12 SNPs for heart failure were proposed as instrumental variables at the genome-wide significance level (p?

SUBMITTER: Tang B 

PROVIDER: S-EPMC7286869 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study.

Tang Bowen B   Yuan Shuai S   Xiong Ying Y   He Qiqiang Q   Larsson Susanna C SC  

Diabetologia 20200408 7


<h4>Aims/hypothesis</h4>Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. We conducted a two-sample bidirectional Mendelian randomisation (MR) study to assess the causal associations of MDD with type 2 diabetes, coronary artery disease (CAD) and heart failure and vice versa.<h4>Methods</h4>We extracted summary-level data for MDD, type 2 diabetes, CAD and heart failure from corresponding published large genome-wide a  ...[more]

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