Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study.

ABSTRACT:

Aims/hypothesis

Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. We conducted a two-sample bidirectional Mendelian randomisation (MR) study to assess the causal associations of MDD with type 2 diabetes, coronary artery disease (CAD) and heart failure and vice versa.

Methods

We extracted summary-level data for MDD, type 2 diabetes, CAD and heart failure from corresponding published large genome-wide association studies of individuals mainly of European-descent. In total, 96 SNPs for MDD, 202 SNPs for type 2 diabetes, 44 SNPs for CAD and 12 SNPs for heart failure were proposed as instrumental variables at the genome-wide significance level (p < 5 × 10^-8). The random-effects inverse-var

SUBMITTER: Tang B 

PROVIDER: S-EPMC7286869 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature