Unknown

Dataset Information

0

Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study.


ABSTRACT: AIMS/HYPOTHESIS:Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. We conducted a two-sample bidirectional Mendelian randomisation (MR) study to assess the causal associations of MDD with type 2 diabetes, coronary artery disease (CAD) and heart failure and vice versa. METHODS:We extracted summary-level data for MDD, type 2 diabetes, CAD and heart failure from corresponding published large genome-wide association studies of individuals mainly of European-descent. In total, 96 SNPs for MDD, 202 SNPs for type 2 diabetes, 44 SNPs for CAD and 12 SNPs for heart failure were proposed as instrumental variables at the genome-wide significance level (p?

SUBMITTER: Tang B 

PROVIDER: S-EPMC7286869 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study.

Tang Bowen B   Yuan Shuai S   Xiong Ying Y   He Qiqiang Q   Larsson Susanna C SC  

Diabetologia 20200408 7


<h4>Aims/hypothesis</h4>Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. We conducted a two-sample bidirectional Mendelian randomisation (MR) study to assess the causal associations of MDD with type 2 diabetes, coronary artery disease (CAD) and heart failure and vice versa.<h4>Methods</h4>We extracted summary-level data for MDD, type 2 diabetes, CAD and heart failure from corresponding published large genome-wide a  ...[more]

Similar Datasets

| S-EPMC7406523 | biostudies-literature
2012-04-27 | E-GEOD-37579 | biostudies-arrayexpress
| S-EPMC9069588 | biostudies-literature
| S-EPMC7682841 | biostudies-literature
| S-EPMC6069804 | biostudies-other
2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
| S-EPMC6112630 | biostudies-literature
| S-EPMC11002219 | biostudies-literature
| S-EPMC6155050 | biostudies-literature
2011-10-05 | GSE19738 | GEO