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Contextual centrality: going beyond network structure.

ABSTRACT: Centrality is a fundamental network property that ranks nodes by their structural importance. However, the network structure alone may not predict successful diffusion in many applications, such as viral marketing and political campaigns. We propose contextual centrality, which integrates structural positions, the diffusion process, and, most importantly, relevant node characteristics. It nicely generalizes and relates to standard centrality measures. We test the effectiveness of contextual centrality in predicting the eventual outcomes in the adoption of microfinance and weather insurance. Our empirical analysis shows that the contextual centrality of first-informed individuals has higher predictive power than that of other standard centrality measures. Further simulations show that when the diffusion occurs locally, contextual centrality can identify nodes whose local neighborhoods contribute positively. When the diffusion occurs globally, contextual centrality signals whether diffusion may generate negative consequences. Contextual centrality captures more complicated dynamics on networks than traditional centrality measures and has significant implications for network-based interventions.

SUBMITTER: Leng Y

PROVIDER: S-EPMC7286920 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Contextual centrality: going beyond network structure.

Leng Yan Y Sella Yehonatan Y Ruiz Rodrigo R Pentland Alex A

Scientific reports 20200610 1

Centrality is a fundamental network property that ranks nodes by their structural importance. However, the network structure alone may not predict successful diffusion in many applications, such as viral marketing and political campaigns. We propose contextual centrality, which integrates structural positions, the diffusion process, and, most importantly, relevant node characteristics. It nicely generalizes and relates to standard centrality measures. We test the effectiveness of contextual cent ...[more]

PMID: 32523009

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Project description:BackgroundAltered right ventricular structure is an important feature of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), but is challenging to quantify objectively. The aim of this study was to go beyond ventricular volumes and diameters and to explore if the shape of the right and left ventricles could be assessed and related to clinical measures. We used quantifiable computational methods to automatically identify and analyse malformations in ARVC patients from Cardiovascular Magnetic Resonance (CMR) images. Furthermore, we investigated how automatically extracted structural features were related to arrhythmic events.MethodsA retrospective cross-sectional feasibility study was performed on CMR short axis cine images of 27 ARVC patients and 21 ageing asymptomatic control subjects. All images were segmented at the end-diastolic (ED) and end-systolic (ES) phases of the cardiac cycle to create three-dimensional (3D) bi-ventricle shape models for each subject. The most common components to single- and bi-ventricular shape in the ARVC population were identified and compared to those obtained from the control group. The correlations were calculated between identified ARVC shapes and parameters from the 2010 Task Force Criteria, in addition to clinical outcomes such as ventricular arrhythmias.ResultsBi-ventricle shape for the ARVC population showed, as ordered by prevalence with the percent of total variance in the population explained by each shape: global dilation/shrinking of both ventricles (44 %), elongation/shortening at the right ventricle (RV) outflow tract (15 %), tilting at the septum (10 %), shortening/lengthening of both ventricles (7 %), and bulging/shortening at both the RV inflow and outflow (5 %). Bi-ventricle shapes were significantly correlated to several clinical diagnostic parameters and outcomes, including (but not limited to) correlations between global dilation and electrocardiography (ECG) major criteria (p = 0.002), and base-to-apex lengthening and history of arrhythmias (p = 0.003). Classification of ARVC vs. control using shape modes yielded high sensitivity (96 %) and moderate specificity (81 %).ConclusionWe presented for the first time an automatic method for quantifying and analysing ventricular shapes in ARVC patients from CMR images. Specific ventricular shape features were highly correlated with diagnostic indices in ARVC patients and yielded high classification sensitivity. Ventricular shape analysis may be a novel approach to classify ARVC disease, and may be used in diagnosis and in risk stratification for ventricular arrhythmias.

Dataset Information

Contextual centrality: going beyond network structure.

Publications

Contextual centrality: going beyond network structure.

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