Ontology highlight
ABSTRACT:
SUBMITTER: Iadarola B
PROVIDER: S-EPMC7287100 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Iadarola Barbara B Xumerle Luciano L Lavezzari Denise D Paterno Marta M Marcolungo Luca L Beltrami Cristina C Fortunati Elisabetta E Mei Davide D Vetro Annalisa A Guerrini Renzo R Parrini Elena E Rossato Marzia M Delledonne Massimo M
Scientific reports 20200610 1
The exome contains many obscure regions difficult to explore with current short-read sequencing methods. Repetitious genomic regions prevent the unique alignment of reads, which is essential for the identification of clinically-relevant genetic variants. Long-read technologies attempt to resolve multiple-mapping regions, but they still produce many sequencing errors. Thus, a new approach is required to enlighten the obscure regions of the genome and rescue variants that would be otherwise neglec ...[more]