Ontology highlight
ABSTRACT:
SUBMITTER: Qi X
PROVIDER: S-EPMC7287781 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Qi Xin X Li Meng M Zhang Xiao-Min XM Dai Xiu-Fen XF Cui Jian J Li De-Hai DH Gu Qian-Qun QQ Lv Zhi-Hua ZH Li Jing J
Molecules (Basel, Switzerland) 20200514 10
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that contributes to cancer progression through multiple processes of cancer development, which makes it an attractive target for cancer therapy. The IL-6/STAT3 pathway is associated with an advanced stage in colorectal cancer patients. In this study, we identified trichothecin (TCN) as a novel STAT3 inhibitor. TCN was found to bind to the SH2 domain of STAT3 and inhibit STAT3 activation and dimerization, thereby ...[more]