Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.
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ABSTRACT:
SUBMITTER: Riquelme E
PROVIDER: S-EPMC7288240 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.
Riquelme Erick E Zhang Yu Y Zhang Liangliang L Montiel Maria M Zoltan Michelle M Dong Wenli W Quesada Pompeyo P Sahin Ismet I Chandra Vidhi V San Lucas Anthony A Scheet Paul P Xu Hanwen H Hanash Samir M SM Feng Lei L Burks Jared K JK Do Kim-Anh KA Peterson Christine B CB Nejman Deborah D Tzeng Ching-Wei D CD Kim Michael P MP Sears Cynthia L CL Ajami Nadim N Petrosino Joseph J Wood Laura D LD Maitra Anirban A Straussman Ravid R Katz Matthew M White James Robert JR Jenq Robert R Wargo Jennifer J McAllister Florencia F
Cell 20190801 4
Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing long-term survival. Using 16S rRNA gene sequencing, we analyzed the tumor microbiome composition in PDAC patients with short-term survival (STS) and long-term survival (LTS). We found higher alpha-diversity in the tumor microbiome of LTS patients and identified an intra-tumoral ...[more]
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