Ontology highlight
ABSTRACT:
SUBMITTER: Luo Z
PROVIDER: S-EPMC7288735 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Luo Zhiyuan Z Mu Lili L Zheng Yue Y Shen Wenchen W Li Jiali J Xu Lichao L Zhong Bo B Liu Ying Y Zhou Yan Y
Journal of molecular cell biology 20200601 5
The release and nuclear translocation of the intracellular domain of Notch receptor (NICD) is the prerequisite for Notch signaling-mediated transcriptional activation. NICD is subjected to various posttranslational modifications including ubiquitination. Here, we surprisingly found that NUMB proteins stabilize the intracellular domain of NOTCH1 receptor (N1ICD) by regulating the ubiquitin-proteasome machinery, which is independent of NUMB's role in modulating endocytosis. BAP1, a deubiquitinatin ...[more]