Ontology highlight
ABSTRACT:
SUBMITTER: Ye X
PROVIDER: S-EPMC7288912 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Aging 20200518 10
Sustained activation of PI3K-Akt-mTOR cascade is important for renal cell carcinoma (RCC) cell progression. GNE-477 is a novel and efficacious PI3K-mTOR dual inhibitor. The current study tested its anti-RCC cell activity. In the primary cultured human RCC cells, GNE-477 potently inhibited cell growth, viability and proliferation, as well as cell cycle progression, migration and invasion. Furthermore, it induced robust apoptosis activation in primary RCC cells, but being non-cytotoxic to HK-2 epi ...[more]