Ontology highlight
ABSTRACT:
SUBMITTER: Kaelber JT
PROVIDER: S-EPMC7289189 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kaelber Jason T JT Jiang Wen W Weaver Scott C SC Auguste Albert J AJ Chiu Wah W
Structure (London, England : 1993) 20200210 6
Members of the family Reoviridae package several copies of the viral polymerase complex into their capsid to carry out replication and transcription within viral particles. Classical single-particle reconstruction encounters difficulties resolving structures such as the intraparticle polymerase complex because refinement can converge to an incorrect map and because the map could depict a nonrepresentative subset of particles or an average of heterogeneous particles. Using the nine-segmented Fako ...[more]