Unknown

Dataset Information

0

A novel drug repurposing approach for non-small cell lung cancer using deep learning.

ABSTRACT: Drug repurposing is an attractive and pragmatic way offering reduced risks and development time in the complicated process of drug discovery. In the past, drug repurposing has been largely accidental and serendipitous. The most successful examples so far have not involved a systematic approach. Nowadays, remarkable advances in drugs, diseases and bioinformatic knowledge are offering great opportunities for designing novel drug repurposing approach through comprehensive understanding of drug information. In this study, we introduced a novel drug repurposing approach based on transcriptomic data and chemical structures using deep learning. One strong candidate for repurposing has been identified. Pimozide is an anti-dyskinesia agent that is used for the suppression of motor and phonic tics in patients with Tourette's Disorder. However, our pipeline proposed it as a strong candidate for treating non-small cell lung cancer. The cytotoxicity of pimozide against A549 cell lines has been validated.

SUBMITTER: Li B 

PROVIDER: S-EPMC7289363 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A novel drug repurposing approach for non-small cell lung cancer using deep learning.

Li Bingrui B   Dai Chan C   Wang Lijun L   Deng Hailong H   Li Yingying Y   Guan Zheng Z   Ni Haihong H  

PloS one 20200611 6

Drug repurposing is an attractive and pragmatic way offering reduced risks and development time in the complicated process of drug discovery. In the past, drug repurposing has been largely accidental and serendipitous. The most successful examples so far have not involved a systematic approach. Nowadays, remarkable advances in drugs, diseases and bioinformatic knowledge are offering great opportunities for designing novel drug repurposing approach through comprehensive understanding of drug info  ...[more]

Similar Datasets

Unknown New Insights Into Drug Repurposing for COVID-19 Using Deep Learning.
| S-EPMC8843052 | biostudies-literature
Unknown A multimodal deep learning-based drug repurposing approach for treatment of COVID-19.
| S-EPMC7525234 | biostudies-literature
Unknown In Silico Screening of Available Drugs Targeting Non-Small Cell Lung Cancer Targets: A Drug Repurposing Approach.
| S-EPMC8778223 | biostudies-literature
Unknown Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing.
| S-EPMC10051080 | biostudies-literature
Unknown Predicting Deep Hypnotic State From Sleep Brain Rhythms Using Deep Learning: A Data-Repurposing Approach.
| S-EPMC7147424 | biostudies-literature
Unknown Machine learning driven drug repurposing strategy for identification of potential RET inhibitors against non-small cell lung cancer.
| S-EPMC9769489 | biostudies-literature
Unknown Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway.
| S-EPMC8526962 | biostudies-literature
Unknown A novel computational approach for drug repurposing using systems biology.
| S-EPMC6084573 | biostudies-literature
Unknown Drug Repurposing in Non-Small Cell Lung Carcinoma: Old Solutions for New Problems.
| S-EPMC9858415 | biostudies-literature
Unknown Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.
| S-EPMC9847512 | biostudies-literature