Ontology highlight
ABSTRACT:
SUBMITTER: Pushin DM
PROVIDER: S-EPMC7289367 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pushin Denis M DM Salikhova Tatiana Y TY Zlobina Ksenia E KE Guria Georgy Th GT
PloS one 20200611 6
Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed. Cumulative effect of dynamic shear on platelet activation via conformational changes of VWF is analysed. The critical condition of shear-induced platelet activation is formulated. The explicit expression for the threshold value of cumulative shear stress as a function of VWF mul ...[more]