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Platelet activation via dynamic conformational changes of von Willebrand factor under shear.

ABSTRACT: Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed. Cumulative effect of dynamic shear on platelet activation via conformational changes of VWF is analysed. The critical condition of shear-induced platelet activation is formulated. The explicit expression for the threshold value of cumulative shear stress as a function of VWF multimer size is derived. The results open novel prospects for pharmacological regulation of shear-induced platelet activation through control of VWF multimers size distribution.

SUBMITTER: Pushin DM 

PROVIDER: S-EPMC7289367 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Platelet activation via dynamic conformational changes of von Willebrand factor under shear.

Pushin Denis M DM   Salikhova Tatiana Y TY   Zlobina Ksenia E KE   Guria Georgy Th GT  

PloS one 20200611 6

Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed. Cumulative effect of dynamic shear on platelet activation via conformational changes of VWF is analysed. The critical condition of shear-induced platelet activation is formulated. The explicit expression for the threshold value of cumulative shear stress as a function of VWF mul  ...[more]

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