Hematological features of persons with COVID-19.

ABSTRACT: We studied admission and dynamic demographic, hematological and biochemical co-variates in 1449 hospitalized subjects with coronavirus infectious disease-2019 (COVID-19) in five hospitals in Wuhan, Hubei province, China. We identified two admission co-variates: age (Odds Ratio [OR]?=?1.18, 95% Confidence Interval [CI] [1.02, 1.36]; P?=?0.026) and baseline D-dimer (OR?=?3.18 [1.48, 6.82]; P?=?0.003) correlated with an increased risk of death in persons with COVID-19. We also found dynamic changes in four co-variates, ? fibrinogen (OR?=?6.45 [1.31, 31.69]; P?=?0.022), ? platelets (OR?=?0.95 [0.90-0.99]; P?=?0.029), ? C-reactive protein (CRP) (OR?=?1.09 [1.01, 1.18]; P?=?0.037), and ? lactate dehydrogenase (LDH) (OR?=?1.03 [1.01, 1.06]; P?=?0.007) correlated with an increased risk of death. The potential risk factors of old age, high baseline D-dimer, and dynamic co-variates of fibrinogen, platelets, CRP, and LDH could help clinicians to identify and treat subjects with poor prognosis.

SUBMITTER: Li Q 

PROVIDER: S-EPMC7289481 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature